Nia and Simon from Gurren lagann
Eureka and Renton from Eureka Seven
Ren and Coud from Elemental Gelade
Spoilers for all three series ahead.
Apparently I'm just more of a fan of couples where the female isn't human. Nia is a artificial human human created by the Anti-Spirals to serve as a sleeper agent, Eureka is a human-form coralian created by the scab coral to help it communicate with humans, and Ren is a magical sword that can transform into a girl.
I guess I just find other couples like Chidori/Sousuke and Ed/Winry rather boring compared to the ones mentioned above