Zatch Bell has the ugliest set of people I've ever seen in an anime, they always make me laugh just by looking at them. I can't even tell some of the humans from the momodo's, some of the humans are damn ugly. Yow this show makes me laugh so hard without being funny
I'd have to say....any non-main character in One Piece? Or any villain......Heck, anyone NOT a Straw Hat pirate, with a few exceptions, like Vivi and some of the CP9 people. Bottom line, there are some UGLY people on that show XD